Dr. Moritsugu has been a dedicated advocate for organ and tissue donation and transplantation. Since 1994, he has been an active participant in the National Donor Family Recognition Programs in Washington, D.C. He has been a member of the Board of Directors of the United Network for Organ Sharing (UNOS), secretary/treasurer and Board member of the Washington Regional Transplant Community (WRTC) and member of the National Advisory Board for the Minority Organ and Tissue Transplant Education Program (MOTTEP). He has also been a past member of the Board of Trustees of the National Kidney Foundation (NKF), the Executive Committee of the National Donor Family Council, and the Washington Regional Transplant Consortium's Donor Family Council, its Public Affairs Committee and its Minority Affairs Committee. In recognition of his continuing efforts in this field, in 2007, the International Congress on Organ Donation named him its inaugural International Ambassador for Organ and Tissue Donation.

Moritsugu was the Acting Surgeon General of the United States from July 2006 to his retirement from the Commissioned Corps of the U.S. Public Health Service in September 2007, after 37 years of active duty. Since 1998, he also served as the Deputy Surgeon General of the U.S., in which he was the principal assistant and advisor to the Surgeon General.

As Vice President for Global Strategic Affairs for LifeScan, a Johnson & Johnson company, Dr. Kenneth Moritsugu is responsible for coordinating the strategic efforts of the Diabetes Franchise of Johnson & Johnson in addressing the diabetes pandemic. He also is chairman of the Johnson & Johnson Diabetes Institute, a global initiative to provide awareness and training in state-of-the-art science, information, and technology relevant to diabetes prevention, awareness, diagnosis and treatment.